Brief Description
Choice of Medicine for the spectrum of diseases with abnormal circulation, tissue perfusion and blood production associated with liver diseases.
चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम्
पुनर्नवा त्रिवृद्व्योषविडङ्गं दारु चित्रकम्||९३||
कुष्ठं हरिद्रे त्रिफला दन्ती चव्यं कलिङ्गकाः| पिप्पली पिप्पलीमूलं मुस्तं चेति पलोन्मितम्||९४||
मण्डूरं द्विगुणं चूर्णाद्गोमूत्रे द्व्याढके पचेत् | कोलवद्गुटिकाः कृत्वा तक्रेणालोड्य ना पिबेत्||९५||
ताः पाण्डुरोगान् प्लीहानमर्शांसि विषमज्वरम् | श्वयथुं ग्रहणीदोषं हन्युः कुष्ठं क्रिमींस्तथा||९६||
इति पुनर्नवामण्डूरम्
| Serial Number | Samskruta Name | Scientific name | Hindi Name | English Name | Quantity for 1000 g | Units | Ratio |
|
|||||||
| 1 | पुनर्नवा मूलम् - Punarnava Mulam | Boerhavia diffusa |
लाल पुनर्नवा कि जड - Lal Punarnava ki Jad
|
Red Spiderling - Roots | 16.66666667 | g | 1 |
| 2 | पालिन्दी / श्यामा त्रिवृत् मूलम् - Palindi / Shyama Trivrut Mulam | Operculina turpethum | काला निशोत् की जड | Transparent Wood Rose, White day glory, Indian jalap | 16.66666667 | g | 1 |
| 3 | नागर / शुण्ठी मूलम् - Nagara / Shunthi Mulam | Zingiber officinale | सोंठ - Sonth | Ginger - Dry Tubers | 16.66666667 | g | 1 |
| 4 | पिप्पली / मागधी / उपकुल्या / कणा / कृष्णा फलम् - Pippali / Magadhi / Upakulya/ Kana / Krushna Phalam | Piper longum | बढी पिप्पली - Badhi Pippali | Indian Long Pepper / Joborandi - Dried Fruit | 16.66666667 | g | 1 |
| 5 | मरिच / ऊषण बीजम् - Maricha / Ushana Beejam | Piper nigrum | कालामिर्च के बीज - Kalamirch ke Beej | Black Pepper - Dried Fruit | 16.66666667 | g | 1 |
| 6 | विडङ्ग फलम् - Vidanga Phalam | Embelia ribes | बावोबरंग / बायुविडंग के फल - Baobarang / Bayuvidanga ke Phal | Embelia - Fruits | 16.66666667 | g | 1 |
| 7 | देवदारु काष्ठ - Devadaru Kashtham | Cedrus deodara | देवदार लकडी - Devadar Lakdi | Himalayan Cedar, Deodar - Logs | 16.66666667 | g | 1 |
| 8 | रक्त चित्रक मूलम् - Rakta Chitraka Mualm | Plumbago indica / Plumbago zeylanica | रक्त / श्वेत चित्रक की जड - Rakta / Rakta / Shveta Chitraka Ki Jad | Ceylon Leadwort, Leadwort - Roots | 16.66666667 | g | 1 |
| 9 | कुष्ठ मूलम् - Kushtha Mulam | Saussurea lappa /Saussurea costus | कूठ की जड - Kooth ki Jad | Indian costus Roots | 16.66666667 | g | 1 |
| 10 | हरिद्रा मूलम् - Haridra Mulam | Curcuma longa | हल्दी - Haldi | Turmeric Roots | 16.66666667 | g | 1 |
| 11 | दारुहरिद्रा मूलम् - 1 - Daruharidra Mulam -1 | Berberis aristata | दार्वी / दारुहल्दी की जड - 1 - Darvi / Daruhaldi ki Jad - 1 | Indian Barberry Roots - 1 | 16.66666667 | g | 1 |
| 12 | आमलकी फलत्वक् - Amalaki phala tvak | Emblica officinalis | आंवला का छिल्का - Avla Chilka | Emblic, Indian gooseberry - Dried Fruit Rind | 16.66666667 | g | 1 |
| 13 | हरीतकी फल त्वक् - Haritaki Phala Tvak | Terminalia chebula | हरड फल छिल्का - Haradphala Chilka | Chebulic Myrobalan, Black Myrobalan - Dried Fruit rind | 16.66666667 | g | 1 |
| 14 | विभीतकी फलत्वक् - Vibhitaki Phala tvak | Terminalia bellirica | बेहेडा फल छिल्का - Beheda Phala Chilkaa | Belleric Myrobalan,Bastard Myrobalan - Dried Fruit rind | 16.66666667 | g | 1 |
| 15 | दन्ती मूलम् - Danti Mulam | Baliospermum montanum | जंग्ली जमालगोटा | Red Physic Nut, wild castor, wild croton, wild sultan seed | 16.66666667 | g | 1 |
| 16 | चव्य काण्डकाष्ठम् - Chavya Kandakashtham | Piper chaba | चबा काण्डभाग - Chaba Kandabhaga | Java Long Pepper - Stem Cuttings | 16.66666667 | g | 1 |
| 17 | इन्द्रयव - Indrayava | Holarrhena antidysenterica | इन्द्रजव - कडवा - Indrajav Kadva | Easter tree, Ivory tree, Tellicherry Bark - Seeds | 16.66666667 | g | 1 |
| 18 | पिप्पली / मागधी / उपकुल्या / कणा / कृष्णा फलम् - Pippali / Magadhi / Upakulya/ Kana / Krushna Phalam | Piper longum | बढी पिप्पली - Badhi Pippali | Indian Long Pepper / Joborandi - Dried Fruit | 16.66666667 | g | 1 |
| 19 | पिप्पली मूलम् - Pippali Mulam | Piper longum | पिप्ला मूल - Pipla Mul | Indian Long Pepper / Joborandi - Stem and Root Cuttings | 16.66666667 | g | 1 |
| 20 | मुस्ता कन्दम् - Musta Kandam | Cyperus rotundus | नागरमोथा की जड - Musta ki Jad | Nut Grass - Tubers | 16.66666667 | g | 1 |
| 21 | मण्डूर भस्मम् / किट्ट भस्मम् - Mandura Bhasmam / Kitta Bhasmam | Ash of Ferric oxide / Ferrous oxide | मण्डूर भस्म - Mandura Bhasma | Incinerate of Oxides of Iron | 666.6666667 | g | 40 |
| 22 | गो मूत्रम् - Go Mutram | Combination of Water, Urea, Minerals, ions and enzymes | गो मूत्र - Go Mutra | Cow Urine | 2,133.34 | ml | 128 |
| Serial No | Samskruta Name | Description | Anupanam |
| 1 | पाण्डुरोगम् - Pandu Rogam | Disease spectrum with altered blood circulation and tissue perfusion resulting in altered colour complexion and stamina of the body | तक्रम् - Takram - Buttermilk |
| 2 | प्लीहरोगम् - Pleeha Rogam | Disease spectrums with Splenomegaly or enlarged spleen | तक्रम् - Takram - Buttermilk |
| 3 | अर्शस् - Arshas | Diseases with swellings and tumours at anal canal | तक्रम् - Takram - Buttermilk |
| 4 | विषम ज्वरम् - Vishama Jvaram | Disease spectrum with remittent or relapsing fever | तक्रम् - Takram - Buttermilk |
| 5 | सर्वाङ्ग शोथम् / सर्वाङ्ग शोफम् - Sarvanga Shopham / Sarvanga Shotham | Disease spectrum which results is water retention in all parts of the body. | तक्रम् - Takram - Buttermilk |
| 6 | ग्रहणी रोगम् - Grahani Rogam | Disease spectrum with altered digestion, absorption and excretion | तक्रम् - Takram - Buttermilk |
| 7 | कुष्ठ - Kushtha | Disease spectrum with altered skin textures and sensations | तक्रम् - Takram - Buttermilk |
| 8 | क्रिमि रोगम् - Krimirogam | Diseases of Worm or insect infestation | तक्रम् - Takram - Buttermilk |
Gingerol
Geranial
Neral
Sesquiterpenes
Beta sesquiphellandrene
Betabisabolene
Arcurcumene
Alphazingiberene
Zingiberene
Shogaol
Diarylheptenone
Diterpenes
Gingesulphonic acid
Monoacyldigalactosyl glycerol
Piperine
Aristolactams
Dioxoaporphines
Isobutyl amide
Longamide
Guineensine
Lignans
Pluviatilol
Methyl pluviatilol
Fargesin
Sesamin
Asarinine
N-isobutyl-deca-trans - 2- trans - 4 - dienamide
Piperolactam A
Cepharadione B
Cepharadione A
Cepharanone B
Isodihydropiperlonguminine
Methylpiperate
Cepharanone B
3,4,5 - Trimethoxycinnamate
Piperidine
Pellitorine
Brachystamide B
Pipataline
Piperrolein B
Pipernonaline
Dehydropipernonaline
Retrofractamide C
Pellitorine
Piperanine
Piperolactam A
Piperolactam B
Quinoline-4
Piperine
Piperatine
Piperidine
N-isobutyl-cicosa-trans-2-trans-4-dienamide
Plumbagin
Vitamin C - Ascorbic Acid
Gallic Acid
Phyllembin
Zeatin
Zeatin riboside
Zeatin nucleotide
Phyllembin
Superoxide dismutase
Tannin
Gallic Acid
Shikimic Acid
Triacontanoic Acid
Palmitic Acid
Beta-sitosterol
Daucosterol
Triethyl ester of chebulic acid
Ethyl ester of gallic acid
Ellagitannins
Terchebulin
Punicalagin
Teaflavin
Triterpene
Chebupentol
Arjungenin
Terminoic acid
Arjunolic acid
Phloroglucinol
Pyrogallol
Beta-sitosterol
Gallic Acid
Ellagic acid
Ethyl ester of gallic acid
Galloyl glucose
Chebulagic acid
Bellaricanin - Cardiac glycoside
Tannin
Piperine
Aristolactams
Dioxoaporphines
Isobutyl amide
Longamide
Guineensine
Lignans
Pluviatilol
Methyl pluviatilol
Fargesin
Sesamin
Asarinine
N-isobutyl-deca-trans - 2- trans - 4 - dienamide
Piperolactam A
Cepharadione B
Cepharadione A
Cepharanone B
Isodihydropiperlonguminine
Methylpiperate
Cepharanone B
3,4,5 - Trimethoxycinnamate
Piperidine
Pellitorine
Brachystamide B
Pipataline
Piperrolein B
Pipernonaline
Dehydropipernonaline
Retrofractamide C
Pellitorine
Piperanine
Piperolactam A
Piperolactam B
Quinoline-4
Ferric oxide
Ferrous oxide
Geranial
Neral
Sesquiterpenes
Beta sesquiphellandrene
Betabisabolene
Arcurcumene
Alphazingiberene
Zingiberene
Shogaol
Diarylheptenone
Diterpenes
Gingesulphonic acid
Monoacyldigalactosyl glycerol
Piperine
Aristolactams
Dioxoaporphines
Isobutyl amide
Longamide
Guineensine
Lignans
Pluviatilol
Methyl pluviatilol
Fargesin
Sesamin
Asarinine
N-isobutyl-deca-trans - 2- trans - 4 - dienamide
Piperolactam A
Cepharadione B
Cepharadione A
Cepharanone B
Isodihydropiperlonguminine
Methylpiperate
Cepharanone B
3,4,5 - Trimethoxycinnamate
Piperidine
Pellitorine
Brachystamide B
Pipataline
Piperrolein B
Pipernonaline
Dehydropipernonaline
Retrofractamide C
Pellitorine
Piperanine
Piperolactam A
Piperolactam B
Quinoline-4
Piperine
Piperatine
Piperidine
N-isobutyl-cicosa-trans-2-trans-4-dienamide
Plumbagin
Vitamin C - Ascorbic Acid
Gallic Acid
Phyllembin
Zeatin
Zeatin riboside
Zeatin nucleotide
Phyllembin
Superoxide dismutase
Tannin
Gallic Acid
Shikimic Acid
Triacontanoic Acid
Palmitic Acid
Beta-sitosterol
Daucosterol
Triethyl ester of chebulic acid
Ethyl ester of gallic acid
Ellagitannins
Terchebulin
Punicalagin
Teaflavin
Triterpene
Chebupentol
Arjungenin
Terminoic acid
Arjunolic acid
Phloroglucinol
Pyrogallol
Beta-sitosterol
Gallic Acid
Ellagic acid
Ethyl ester of gallic acid
Galloyl glucose
Chebulagic acid
Bellaricanin - Cardiac glycoside
Tannin
Piperine
Aristolactams
Dioxoaporphines
Isobutyl amide
Longamide
Guineensine
Lignans
Pluviatilol
Methyl pluviatilol
Fargesin
Sesamin
Asarinine
N-isobutyl-deca-trans - 2- trans - 4 - dienamide
Piperolactam A
Cepharadione B
Cepharadione A
Cepharanone B
Isodihydropiperlonguminine
Methylpiperate
Cepharanone B
3,4,5 - Trimethoxycinnamate
Piperidine
Pellitorine
Brachystamide B
Pipataline
Piperrolein B
Pipernonaline
Dehydropipernonaline
Retrofractamide C
Pellitorine
Piperanine
Piperolactam A
Piperolactam B
Quinoline-4
Ferric oxide
Ferrous oxide
| Rasa | कटु - Katu - Pungent तिक्त - Tikta - Bitter कषाय - Kashaya - Astringent |
|---|---|
| Guna | तीक्ष्णम् - Tikshnam - Drug action which irritates body by its Pungent quality लघु गुणम् - Laghu Gunam - Drug property which induces lightness to body उष्णं गुणम् - Ushna Gunam - Drug action which imparts heat रूक्ष गुणम् - Ruksha Gunam - Drug action which imparts dryness श्लक्ष्ण गुणम् - Shlakshna Gunam - Drug property which imparts smoothness सान्द्र गुणम् - Sandra Gunam - Drug action which imparts thickness or tightness or tight binding मृदु गुणम् - Mrudu Gunam - Drug action which imparts softness सर गुण - Saraguna - Drug action which imparts movement सूक्ष्म गुणम् - Sukshma Gunam - Drug property by virtue of which molecules of drug can eneter into minutetst spaces of body विशद गुणम् - Vishada Gunam - Drug action which cleanses the body |
| Veerya | Ushna veerya |
| Vipaka | Katu |
| Prabhava | पाण्डुरोगहरम् - Pandurogaharam - Drug action which cures disease spectrum with altered blood circulation and tissue perfusion |
| Anupanam | तक्रम् - Takram - Buttermilk | modal-content
| Sl.No. | Disease Factor | Name of the combination | Form of the combination | Reference | Combination products | Procedure |
|---|---|---|---|---|---|---|
| 1 | प्लीह रोगम् / प्लीहोदरम् / प्लीह वृद्धिः - Pliha Rogam / Pleehodaram / Pleeha Vruddhi - Disease spectrum with enlarged spleen | पुनर्नवा मण्डूरम् - 1 - Punarnava Manduram - 1 | मण्डूरम् - Manduram - Iron oxide formulations | चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम् | ||
| 2 | पाण्डुरोगम् - Pandurogam - Disease spectrum with altered blood circulation and tissue perfusions and blood production | पुनर्नवा मण्डूरम् - 1 - Punarnava Manduram - 1 | मण्डूरम् - Manduram - Iron oxide formulations | चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम् | ||
| 3 | अर्शस् - Arshas - Diseases with swellings and tumours at anal canal | पुनर्नवा मण्डूरम् - 1 - Punarnava Manduram - 1 | मण्डूरम् - Manduram - Iron oxide formulations | चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम् | ||
| 4 | विषम ज्वर - Vishama jvara - Disease spectrum with remittent fever | पुनर्नवा मण्डूरम् - 1 - Punarnava Manduram - 1 | मण्डूरम् - Manduram - Iron oxide formulations | चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम् | ||
| 5 | सर्वाङ्ग शोथ/ शोफ - Sarvanga shotha - Anasarca, Edema | पुनर्नवा मण्डूरम् - 1 - Punarnava Manduram - 1 | मण्डूरम् - Manduram - Iron oxide formulations | चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम् | ||
| 6 | ग्रहणी रोगम् - Grahani rogam - Disease spectrum with altered digestion, absorption and excretion | पुनर्नवा मण्डूरम् - 1 - Punarnava Manduram - 1 | मण्डूरम् - Manduram - Iron oxide formulations | चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम् | ||
| 7 | कुष्ठम् - Kushtha | पुनर्नवा मण्डूरम् - 1 - Punarnava Manduram - 1 | मण्डूरम् - Manduram - Iron oxide formulations | चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम् | ||
| 8 | क्रिमि रोग (Krimi roga) | पुनर्नवा मण्डूरम् - 1 - Punarnava Manduram - 1 | मण्डूरम् - Manduram - Iron oxide formulations | चरकसंहिता - चिकित्सास्थानम् - १६. पाण्डुरोगचिकित्सितम् |
| Disease Factors |
|---|
| Serial Number | Title | Result |
| 1 | A Review of Literature on Punarnavadi Mandura: An Ayurvedic Herbo-Mineral Preparation | Given the efficacy of Punarnavadi Mandura in Iron Deficiency Anemia (IDA), at all ages, its usage should be fostered more in Indian communities especially the rural communities where IDA is endemic |
| 2 | A clinical study of Punarnava Mandura in the management of Pandu Roga in old age (geriatric anemia) | Punarnava Mandura may work as Rasayana in geriatric anemia by providing highly significant results on clinical features of Pandu Roga, Dehabala, Agni Bala and Sattwa Bala and by improving QOL. of patients of geriatric anemia. |
| 3 | Clinical efficacy of Punarnava Mandura and Dhatri Lauha in the management of Garbhini Pandu (anemia in pregnancy) | Punarnava Mandura is more effective on Garbhini Pandu in comparison to Dhatri Lauha. |
| 4 | Assessment of Role of Punarnava Mandur in Iron Deficiency Anemia (Pandu Roga) as per Hematogical Parameters: a Clinical Study | Punarnava Mandura is more effective than Ferrous Sulphate in the treatment of Iron Deficiency Anemia |
| 5 | Therapeutic efficacy of Punarnavadi mandura against phenylhydrazine-induced hemolytic anemia in rats | The in vivo studies confirm the ability of Punarnavadi Mandura to reverse pathological changes associated with hemolytic anemia at 100 mg/kg and 200 mg/kg concentration. It restored hemoglobin, bilirubin and white blood cell levels to normal and reduced reticulocytes, hemosiderin and Gamna Gandy bodies in the liver, spleen and kidney. In silico studies suggested that the key constituents in Punarnavadi Mandura interact with high affinity to erythropoietic receptor which could contribute to erythropoiesis. The in silico study also predicted that the phytoconstituents of Punarnavadi Mandura could inhibit TNF-α activity which was validated using gene expression studies. |
| 6 | Clinical Efficacy and Safety of Punarnavadi Mandura and Dadimadi Ghrita in the Management of Iron Deficiency Anemia - A Prospective Open-label Multicenter Study | A significant improvement in symptoms of anemia, such as weakness, fatigue, dizziness, and headache, was also seen. The treatment was found to be safe and effective in the patients with iron deficiency anemia as all the safety parameters were within the stipulated range. No adverse drug reaction or adverse events were reported during the trial period. Punarnavadi Mandura and Dadimadi Ghrita administered together in the above-mentioned dose were found effective and safe in patients suffering from iron deficiency anemia. |
| 7 | Clinical Safety of Selected Ayurvedic Formulations in Iron Deficiency Anemia | The findings in the three different clinical studies clearly reveal that Punarnavadi Mandura, Navayasa Churna, Dhatri Lauha, and Dadimadi Ghrta are clinically safe, effective, and tolerable. |
| Type | Operator | Value | Unit | Frequency | Duration | Comment | |
|---|---|---|---|---|---|---|---|
| Adult Dosage | वटी / गुटिका - Vati / Gutika - Pills | <= | 10 | g | 1 times / day | 15 days | |
| Child Dosage | वटी / गुटिका - Vati / Gutika - Pills | <= | 5 | g | 1 times / day | 15 days |
