श्वेत चित्रक मूलम् - Shveta Chitraka Mulam
Scientific Name: Plumbago zeylanica
Hindi Name: सफ़ेद चीता की जड / सफ़ेद चित्रक के जड - Safed Cheeta ki jad / Safed Chitraka ki Jad
English Name: White Ceylon Leadwort / Leadwort - Dry Roots
Category: Plant Parts
Sub-Category: मूलम् - Mulam - Roots
Out of Stock
Brief Description
Drug of Choice in inflammatory Digestive Disorders.
चरकसंहिता - सूत्रस्थानम् - २५. यज्जःपुरुषीयोऽध्यायः
चित्रकमूलं दीपनीयपाचनीयगुदशोथार्शःशूलहराणां
अष्टाङ्गहृदयम् - उत्तरस्थानम् - ३९. रसायनविधिरध्यायः
यथास्वं चित्रकः पुष्पैर्ज्ञेयः पीतसितासितैः | यथोत्तरं स गुणवान् विधिना च रसायनम्||६२||
छायाशुष्कं ततो मूलं मासं चूर्णीकृतं लिहन् | सर्पिषा मधुसर्पिर्भ्यां पिबन् वा पयसा यतिः||६३||
अम्भसा वा हितान्नाशी शतं जीवति नीरुजः | मेधावी बलवान् कान्तो वपुष्मान् दीप्तपावकः||६४||
तैलेन लीढो मासेन वातान् हन्ति सुदुस्तरान् | मूत्रेण श्वित्रकुष्ठानि पीतस्तक्रेण पायुजान्||६५||
सर्वाङ्गसुन्दरी व्याख्या
चित्रको यथायोगं पुष्पैः पीतैः शुक्लैः कृष्णैश्च यथोत्तरं गुणवान् वेदितव्यः| विधिना च प्रयुक्तो रसायनं स्यात्|
तस्माच्चित्रकात् मूलं छायाशुष्कं मासं चूर्णीकृतं घृतेन मधुघृताभ्यां वा लिह्यात्| पयसा वा ब्रह्मचारी पिबेत्| पानीयेन वा हितान्नभोजनः सन् पिबेत्| सुखी मेधावान् बलवान् रमणीयो वपुष्मान् दीप्ताग्निः समाः शतं जीवति|
सं-तैलेन लीढश्चित्रको मासेन दारुणान् वातान् जयति| गोमूत्रेण पीतः श्वित्रकुष्ठानि हन्ति| तक्रेण पीतोऽर्शांसि जयेत्|
कैयदेवनिघण्टु - १. ओषधिवर्ग
चित्रको दहनो वह्निः पाठीको दारुणोऽरुणः ||११७८||
व्यालो हुताशो हुतभुक् पाली पाठी च पावकः | ज्योतिर्ज्वालोऽनलो द्वीपी शिखाग्निर्ज्वलनः शठः ||११७९||
चित्रको दीपनस्तिक्तः कटुः पाके रसे लघुः | अग्निवत् पाचनो रूक्षो वीर्योष्णो रोचनो जयेत् ||११८०||
ग्रहणीकफवातामशोफकुष्ठोदरकृमीन् | कटुकत्वात् कफं हन्ति तिक्तत्वात् पित्तनाशनः ||११८१||
औष्ण्याद् वातं प्रशमयेत् त्रिदोषग्नोऽग्निदीपनः | तच्छाकं लघु सङ्ग्राहि कफपित्तविनाशनम् ||११८२||
धन्वन्तरिनिघण्टु - २. शतपुष्पादिवर्ग
चित्रको दहनो व्यालः पाटिनो दारुणोऽग्निकः | ज्योतिष्को वल्लरी वह्निः पाली पाठी कटुः शिखी ||८५||
कृष्णारुणोऽनलो द्वीपी चित्रभानुश्च पावकः | चित्रकोऽग्निसमः पाके कटुकः कफशोफजित् |
वातोदरार्शोग्रहणीक्षयपाण्डुविनाशनः ||८६||
निघण्टुशेष - २. गुल्मकाण्ड
चित्त्रके वल्लरी व्यालः पाठीनो दारुणः कुटः | ज्योतिष्को जरणोऽग्न्याख्यो वलिन द्वीपि-पाठिनः ||२४८||
निघण्टुशेषटीका व्याख्या (श्रीवल्लभगणि कृत)
चेतति चित्, चितः-जन्तून् त्रायते चित्त्रः, क्वचित् सिद्ध. ५.१.१७१ इति ङः, स्वार्थिके के चित्त्रकः, तत्र| वलि वल्लि संवरणे वल्लते वल्लरी, जठर-क्रकर-हैमोणादिसू. ४०३] इत्यरे निपात्यते| विशेषेण आ-समन्ताद् अडति लाति वा व्यालः, अत्र डस्य लत्वमैक्यात्| पठति पाठीनः, पठेर्णित् हैमोणादिसू. २८७ इति णिदीनः| दॄश् विदारणे णौ दारयति दारुणः, ऋ-कॄ-वॄ-धृ-दारिभ्य उणः हैमोणादिसू. १९६] इति उणः| कुटत् कौटिल्ये कुटति कुटः, नाम्युपान्त्य [सिद्ध. ५.१.५४] इति कः| ज्योतिरेव ज्योतिष्कः| जीर्यते अनेन जरणः| अग्नेराख्याऽस्य अग्न्याख्यः| वलिः-त्वक्सङ्कोचोऽस्त्यस्य वलिनः, अङ्गादित्वान्नः| द्वीपोऽस्त्यस्य द्वीपी| पाठोऽस्यास्तीति पाठी| आह च–
चित्रको दहनो व्यालः पाठीनो दारुणोऽग्निकः| ज्योतिष्को वल्लरी वह्निः पाठी पाली कुटः शिखी|| [धन्व. वर्ग २ श्लो. ८०] इति|
एतस्य लोके चित्रक इति प्रसिद्धिः||२४८||
भावप्रकाश-पूर्वखण्ड-मिश्रप्रकरण - २. हरीतक्यादिवर्ग
चित्रकोऽनलनामा च पाठी व्यालस्तथोषणः | चित्रकः कटुकः पाके वह्निकृत्पाचनो लघुः |
रूक्षोष्णो ग्रहणीकुष्ठशोथार्शःकृमिकासनुत् | वातश्लेष्महरो ग्राही वातर्शःश्लेष्मपित्तहृत् ||६४||
मदनपालनिघण्टु - २. शुण्ठ्यादिवर्ग
चित्रको हुतभुग् व्यालो दारुणो दहनोऽरुणः | अग्निपाली हविःपाली वह्निनाम विशेषतः ||२१||
चित्रकः कटुकः पाके वह्निकृत्पाचनो लघुः | रूक्षोष्णो ग्रहणीकुष्ठशोफार्शः कृमिकासजित् |
श्लेष्मानिलहरो ग्राही तच्छाकं श्लेष्मपित्तनुत् ||२२||
मदनादिनिघण्टु - १. प्रथमगण
चित्रको दहनो वह्निः शिख्यग्निः पावकोऽनलः | ज्योतिर्ज्वालो दीपसञ्ज्ञा पाठिनो दारुणोऽरुणः ||२९||
चित्रकोऽग्निसमः पाके शोफार्शः कृमिकुष्ठहा | कफवातप्रशमनो विधिना च रसायनम् ||३०||
माधवद्रव्यगुण - १. विविधौषधिवर्ग
चित्रकोऽग्निसमः पाके शोथार्शःकृमिकुष्ठहा |
राजनिघण्टु - ६. पिप्पल्यादिवर्ग
चित्रकोऽग्निश्च शार्दूलश्चित्रः पाली कटुः शिखी | कृशानुर्दहनो व्यालो ज्योतिष्कः पालकस्तथा ||४३||
अनलो दारुणो वह्निः पावकः शबलस्तथा | पाठी द्वीपी च चित्राङ्गो ज्ञेयः शूरश्च विंशतिः ||४४||
चित्रकोऽग्निसमः पाके कटुः शोफकफापहः | वातोदरार्शोग्रहणीकृमिकण्डूतिनाशनः ||४५||
रक्तचित्रक (चित्रकविशेष)
कालो व्यालः कालमूलोऽतिदीप्यो मार्जारोऽग्निर्दाहकः पावकश्च |
चित्राङ्गोऽयं रक्तचित्रो महाङ्गः स्याद्रुद्राह्वश्चित्रकोऽन्यो गुणाढ्यः ||४६||
स्थूलकायकरो रुच्यः कुष्ठघ्नो रक्तचित्रकः | रसे नियामको लोहे वेधकश्च रसायनः ||४७||
राजवल्लभनिघण्टु - ६. औषधाश्रयपरिच्छेद
चित्रकोऽग्निसमः पाके शोथार्शःकृमिकुष्ठहा ||८६||
लघुनिघण्टु
चित्रके दहनो व्यालः पाठीनो दारुणो वृकः | धनञ्जयोऽग्निमन्थश्च मार्जारो दीपनोऽनलः ||२७||
चित्रकोऽग्निसमः पाके शोफार्शःकृमिकुष्ठजित् |२८|
सरस्वतीनिघण्टु - ३. उलपवर्ग
चित्रकः स्फोटको दद्रुवैरी पावकसञ्ज्ञकः ||१२||
रक्तश्वेतादिपुष्पाश्च चित्रकानामतो विदुः |१३|
सोढलनिघण्टु - नामसङ्ग्रह (प्रथम भाग) - २. शतपुष्पादिवर्ग
चित्रके दहनो व्यालः पाठीनो दारुणोऽग्निकः ||३३८||
ज्योतिष्को वल्लरी द्वीपी पाठी पाली कटुः शिखी | व्यालकोलो हिताङ्गश्च मार्जारो दीपकस्तथा ||३३९||
सोढलनिघण्टु - गुणसङ्ग्रह (द्वितीय भाग) - २. शतपुष्पादिवर्ग
चित्रकोऽग्निसमः पाके शोफार्शःकृमिकुष्ठहा ||३०४||
नागरं दीपनं वृष्यं ग्राहि हृद्यं विबन्धनुत् |
| Sl.No | Raw Material | Variant | Ratio | Quantity Required for 1000g | Unit |
|---|
| Rasa | कटु - Katu - Pungent तिक्त - Tikta - Bitter |
|---|---|
| Guna | लघु गुणम् - Laghu Gunam - Drug property which induces lightness to body तीक्ष्णम् - Tikshnam - Drug action which irritates body by its Pungent quality उष्णं गुणम् - Ushna Gunam - Drug action which imparts heat रूक्ष गुणम् - Ruksha Gunam - Drug action which imparts dryness खर गुणम् - Khara Gunam - Drug action which imparts roughness द्रव गुणम् - Dravagunam - Drug action which imparts liquid state मृदु गुणम् - Mrudu Gunam - Drug action which imparts softness सर गुण - Saraguna - Drug action which imparts movement सूक्ष्म गुणम् - Sukshma Gunam - Drug property by virtue of which molecules of drug can eneter into minutetst spaces of body विशद गुणम् - Vishada Gunam - Drug action which cleanses the body |
| Veerya | Ushna veerya |
| Vipaka | Katu |
| Prabhava | दीपनपाचनम् - Deepanapachanam - Drug action which amplifies metabolism and scavenges metabolic wastes |
| Anupanam | रोगोपशमन अनुपानम् - Anupana according to the diseases. | modal-content
| Sl.No. | Disease Factor | Name of the combination | Form of the combination | Reference | Combination products | Procedure |
|---|
| Disease Factors |
|---|
| Serial Number | Title | Result |
| 1 | Antibacterial activity of plumbagin and root extracts Of plumbago zeylanica |
This work assesses the antibacterial activity of plumbagin (5-hydroxy-2-methylnaphthalene-1,4-dione) and of methanol, chloroform and aqueous extracts of Plumbago zeylanica L. root against various pathogenic bacteria, and the minimum inhibitory concentrations (MICs). Plumbagin and chloroform extracts of Plumbago zeylanica L. root showed antibacterial activity against Escherichia coli, Salmonella typhi and Staphylococcus aureus. Inhibition against Klebsiella pneumoniae, Serratia marcescens and Bacillus subtilis was moderate, and lower against Proteus vulgaris and Pseudomonas aeruginosa. The methanolic extract exhibited moderate activity and the aqueous extract weak activity against the bacterial strains as assessed by disc diffusion assays. The bioactive compound plumbagin and extract of Plumbago zeylanica root show a wide spectrum of antibacterial activity. The compound shows promise as a new drug for various bacterial infectious diseases. |
| 2 | Anti-inflammatory and cytotoxic effects of extract from Plumbago zeylanica |
Plumbago species (Family-Plumbaginaceae) are one of the most important medicinal plants which are used for anti-inflammatory, antimicrobial diseases. Our work involves the study of anti inflammatory and cytotoxic effects of Plumbago zeylanica. The root of P. zeylanica extracted with methanol was used for determining the anti inflammatory effects. The methanolic extracts at 300 and 500 mg/kg produced 31.03 and 60.3% inhibition of acute inflammation, respectively, in Carrageenin induced raw paw oedema confirming that P. zeylanica roots are effective against acute inflammation. For the evaluation of cytotoxicity, the crude dichloromethane extract was subjected to silica gel column chromatography and 120 fractions were collected. Their structures were elucidated with the help of spectroscopic techniques. High performance liquid chromatography (HPLC) was performed to determine the purity of gugultetrol-18-ferrulate in crude extract and the structure of betasitosterol and gugultetrol-18-ferrulate was identified using nuclear magnetic resonance spectroscopy analysis ( 1H and 13C NMR), Infra red and mass spectroscopy. The lethal concentration (LC50) value was observed for crude extract, betasitosterol, gugultetrol-18-ferrulate and it was found to be 90, 75 and 65 ppm, respectively. The use of Plumbago species as an effective anti inflammatory agent and its cytotoxic effects have been ascertained and proved. |
| 3 | Antioxidant properties of Plumbago zeylanica, an Indian medicinal plant and its active ingredient, plumbagin | Plumbago zeylanica (known as 'Chitrak') is a useful Indian medicinal plant. The root of the plant and its constituents are credited with potential therapeutic properties including anti-atherogenic, cardiotonic, hepatoprotective and neuroprotective properties. To examine possible mechanisms of action of P. zeylanica (Chitrak), in relation to its reported beneficial properties, antioxidant effects of the aqueous/alcoholic extracts of root, corresponding to medicinal preparations, and the active ingredient, plumbagin, were studied. Methods used included: ferric reducing/antioxidant power (FRAP), radical scavenging of 1,1-diphenyl-2-picryl hydrazyl (DPPH) and 2,2'-azobis-3-ethylbenzthiazoline-6-sulfonic acid (ABTS), lipid peroxidation in rat liver mitochondria induced by different agents, and estimating phenolic and flavonoid content. In FRAP/DPPH assays, boiled ethanolic extracts were the most effective, while in the ABTS assay boiled aqueous extracts were the most efficient. These extracts also significantly inhibited lipid peroxidation induced by cumene hydroperoxide, ascorbate-Fe2+ and peroxynitrite and contained high amounts of polyphenols and flavonoids. To examine the mechanisms of action in detail, antioxidant and pulse radiolysis studies with plumbagin were conducted. The hydroxyl (•OH), alkyl peroxyl (CCl3OO•), linoleic acid peroxyl (LOO•), and glutathiyl (GS•) radicals generate a phenoxyl radical upon reaction with plumbagin. The bimolecular rate constants were: •OH, 2.03 x 109 dm3mol–1s–1; CCl3OO•, 1.1 x 109 dm3mol–1s–1; LOO•, 6.7 x 107 dm3mol–1s–1; and GS•, 8.8 x 108 dm3mol–1s–1. In conclusion, our studies reveal that extracts of P. zeylanica and its active ingredient plumbagin have significant antioxidant abilities that may possibly explain some of the reported therapeutic effects. |
| 4 | Medicinal, Biological and Pharmacological Aspects of Plumbago zeylanica (Linn.) |
The present review deals with chemical compounds, medicinal properties, biological activities and pharmacological effects of Plumbago zeylanica. Plumbago zeylanica (Linn.) belongs to family Plumbaginaceae, commonly known as Chitrak is one of the medicinal plants used in the Indian traditional system of medicine. Traditionally P. zeylanica is used as a stimulant digestant, expectorant, laxative and in the treatment of muscular pain and rheumatic diseases. Some parts of P. zeylanica are used in various pharmacological activities. The different parts of P. zeylanica are used for various ethnomedicinal purposes and investigations have been carried out on different chemical compounds such as plumbagin and other compounds of this plant. Its biological activities like antibacterial, antimycotic, antiviral, antiplasmodial, leishmanicidal, trypanocidal and anticarcinogenic have been studied along with pharmacological effects of it. |
| 5 | Heneicosane—A novel microbicidal bioactive alkane identified from Plumbago zeylanica L | Today the quick advancement of multi drug resistance in microorganisms is expanding worldwide and the related medical issues for the treatment of infectious diseases that researchers claim could return to the stage of the pre-antibiotic era. Medicinal plants possess a potential holistic role for the provision of drugs to cure microbial infections. The present work, has aimed to isolate and analyze the new bioactive molecule and to test their antimicrobial activities from the Plumbago zeylanica L leaf extracts. For analyzing the phytochemistry and microbicidal activities of the herb, extracts with various solvents have been used. The various crude leaf extracts with antimicrobial activity was treated against pathogenic microorganisms such as two Gram positive, two Gram negative, one acid fast staining bacteria and one fungus using agar well method. New bioactive molecule was isolated via GC–MS, TLC, HPLC, FTIR and NMR spectrum. Current study had used ethyl acetate leaf extract and exhibited excellent antimicrobial activity compared with other extracts and conventional drugs. The ethyl acetate extract was analyzed by GC–MS which was detected in fifteen compounds, followed by TLC analysis to elucidate the ten compounds with ten fractions. Among the active fractions, a single compound was detected using HPLC analysis. The identified bioactive molecule Heneicosane was used for measuring the antimicrobial activity. Depending on the results obtained, it was verified that heneicosane exhibited excellent antimicrobial activity against Streptococcus pneumoniae 31 ± 0.64 mm and Aspergillus fumigatus 29 ± 0.86 mm respectively at 10 μg/ml concentrations. Hence this study derives its novelty in isolating the bioactive molecule with pronounced microbicidal role from the herbal source mentioned. |
| 6 | Potential anti-inflammatory activity of plumbago zeylanica | Oral administration of dichloromethane extract of Plumbago zeylanica (DMEPZ) shown a significant (p<0.05) dose-dependent protection against carrageenan-induced paw edema. At 1st hr, P. zeylanica shown an inhibition effect of edema in the different doses of 250 mg/kg and 500 mg/kg were found to be 28.57 and 31.79%, respectively. At 3rd hrs, the paw edema inhibition was found to be 30.70 and 40.15%, respectively. Diclofenac (25 mg/kg) had effect of 34.10 and 41.73% (p<0.001) inhibition of paw edema at in 1 and 3 hrs. P. zeylanica 500 mg/kg showed percentage inhibition of wet and dry cotton pellet granuloma in rats 55.84% and 47.92%, respectively. Thus, the present study revealed that the DMEPZ offered significant protection against inflammation. |
| Type | Operator | Value | Unit | Frequency | Duration | Comment | |
|---|---|---|---|---|---|---|---|
| Adult Dosage | सूक्ष्म चूर्णम् - Sukshma Churnam - Fine Powder | <= | 2 | g | 1 times / day | 15 days | |
| कषायम् - kashayam - Decoctions | <= | 30 | ml | 3 times / day | 15 days | ||
| Child Dosage | सूक्ष्म चूर्णम् - Sukshma Churnam - Fine Powder | <= | 1 | g | 1 times / day | 15 days | |
| कषायम् - kashayam - Decoctions | <= | 10 | ml | 3 times / day | 15 days |
